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TECHNICAL NOTES ON CPP: Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats
Author(s) -
Herzig Volker,
Schmidt Werner J.
Publication year - 2007
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2007.00060.x
Subject(s) - conditioned place preference , amygdala , preference , psychology , expression (computer science) , neuroscience , anesthesia , pharmacology , medicine , addiction , computer science , mathematics , statistics , programming language
The effect of transient inactivation of the amygdala on expression of cocaine conditioned place preference (CPP) and locomotion was studied. We found that rats with bilateral but not unilateral amygdala cannula placement exhibited increased CPP expression during a vehicle and a cocaine test as well as increased cocaine‐induced hyper‐locomotion. We discuss the observed effects as being caused by the cannulation per se and we conclude that the applied cannulation produced an increased responsiveness of the amygdala by a yet undetermined mechanism.