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GENETIC STUDY: The polymorphism GABA B R1 T1974C [rs29230] of the GABA B receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures
Author(s) -
Köhnke Michael,
Schick Sandra,
Lutz Ulrich,
Köhnke Annette,
Vonthein Reinhard,
Kolb Werner,
Batra Anil
Publication year - 2006
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1111/j.1369-1600.2006.00013.x
Subject(s) - gabab receptor , alcohol withdrawal syndrome , polymorphism (computer science) , genotyping , alcohol dependence , alcohol , genotype , allele , ethanol , receptor , medicine , candidate gene , gabaa receptor , gene , genetics , biology , biochemistry
As the inhibitory neurotransmitter gamma aminobutyric acid (GABA) modulates ethanol consumption, alcohol withdrawal symptoms and seizure generation by interacting with the GABA B receptor, the genes encoding for the GABA B receptor can be considered as candidate genes for alcoholism and alcohol withdrawal seizures (AWS). As the polymorphism GABA B R1 T1974C [rs29230] of the GABA B receptor gene had been associated with alcoholism and EEG abnormalities in prior studies, the present examination investigated if the polymorphism is associated with the diagnosis of alcoholism or AWS. After genotyping the allele and genotype frequencies of a group of alcoholics with a history of AWS ( n = 69) were compared with the results of a group of alcoholics with only mild withdrawal symptoms ( n = 97). Additionally a group of healthy controls ( n = 101) was compared with individuals with the diagnosis of alcoholism ( n = 220). As no significant differences were found between the compared groups, this study gave no further evidence for GABA B R1 T1974C [rs29230] as a candidate for alcoholism or AWS.