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Molecularly targeted therapies for melanoma
Author(s) -
Liu Lucinda S.,
Colegio Oscar R.
Publication year - 2013
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2012.05829.x
Subject(s) - medicine , vemurafenib , ipilimumab , melanoma , imatinib , metastatic melanoma , dermatology , oncology , cancer research , cancer , immunotherapy , myeloid leukemia
Systemic and topical targeted therapies are emerging as a rational approach to the management of skin cancers. In this article, we review the molecular pathways critical to the development of melanoma and the novel pharmacologic agents that have been rationally designed to target it. Included is a review of vemurafenib, imatinib, and ipilimumab for metastatic or unresectable melanoma.