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The investigation of the possible relationship between C oxsackie viruses and pemphigus
Author(s) -
Kaçar Nida,
Cevahir Nural,
Demirkan Neşe,
Şanlı Berna
Publication year - 2014
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2012.05699.x
Subject(s) - medicine , pemphigus , dermatology , virology
Background Pemphigus is a group of autoimmune bullous diseases on which the etiopathogenesis of several viruses has been blamed. Coxsackie viruses ( CV s) are the causative agents of hand, foot, and mouth disease, and herpangina, which have been strongly associated with several autoimmune diseases. The onset of pemphigus after CV infection and cephalosporin use has been reported. Objective To detect the presence of CV in patients with pemphigus. Materials and methods Reverse transcriptase‐polymerase chain reaction analysis for CV RNA sequences and immunohistochemical staining for the CV and adenovirus receptor expression were performed on patient skin samples. CV ‐ IgM and ‐IgG serum levels were analyzed. Results Thirty‐two patients and 40 controls were investigated. Neither the CV and adenovirus receptor expression nor CV RNA sequences was established in the skin samples of patients. The ratio of CV ‐ IgG positivity was higher in patients (12.5%) than in the controls (5%; P > 0.05). Conclusion Our preliminary results indicate that the viral genome of CV does not become persistent in the skin. Further studies with a larger number of cases are needed to clarify the place of CV s in the etiopathogenesis of pemphigus.