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Dermal delivery by niosomes of black tea extract as a sunscreen agent
Author(s) -
Yeh MengI,
Huang HsiuChin,
Liaw JiaHorng,
Huang MinChuan,
Huang KueiFen,
Hsu FengLin
Publication year - 2013
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2012.05587.x
Subject(s) - niosome , penetration (warfare) , permeation , gallic acid , transdermal , medicine , caffeine , chromatography , pharmacology , traditional medicine , membrane , chemistry , vesicle , organic chemistry , biochemistry , antioxidant , operations research , engineering , endocrinology
Objectives The primary objective of this study was to investigate the feasibility of using niosomes as a delivery vehicle for the dermal administration in vitro of black tea extract (BTE) as a sunscreen. Methods Multi‐lamellar niosomes were obtained by means of a previously reported method of lipid hydration films. In vitro penetration experiments through nude mouse skin were carried out to evaluate the potential of niosomes as a dermal formulation. The nude mouse skin membrane allowed the effects of penetration with a niosome formulation to be evaluated. Penetration rates of caffeine‐ and gallic acid‐loaded niosomes in a steady state were higher than dispersion in aqueous solutions. Results For skin permeation, higher transdermal absorption rates were seen with solutions of caffeine and gallic acid. Conclusions In the near future, BTE as a sunscreen agent will be dermally delivered by niosomes.