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Expression of Fas and Fas ligand in primary cutaneous squamous cell carcinoma in association with grade of tumor differentiation
Author(s) -
Lee Young Bok,
Kyung Kim Eun,
Park Hyun Jeong,
Cho Baik Kee,
Park Young Min,
Kim Jin Woo,
Yoo Nam Jin,
Park Yong Gyu,
Oh Shin Taek
Publication year - 2013
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2012.05525.x
Subject(s) - fas ligand , immunostaining , pathology , immunohistochemistry , fas receptor , medicine , staining , tissue microarray , exact test , carcinoma , apoptosis , biology , programmed cell death , biochemistry
Background The aim of this study was to evaluate whether Fas (CD95) and Fas ligand (FasL) immunoreactivity in cutaneous squamous cell carcinoma (SCC) are correlated with grade of tumor differentiation. Methods A total of 31 cutaneous SCC specimens excised during 1997–2004 were collected from the four branch hospitals of the Catholic University of Korea. A tissue microarray technique was used for immunohistochemical staining. Expression of Fas and FasL was evaluated in correlation with the grade of tumor differentiation. Statistical analysis was performed using Fisher’s exact test and exact trend test. Results Six of 31 SCCs exhibited strong (+++) intensity for Fas immunostaining, and all of these were well differentiated. Five of 31 SCCs exhibited strong (+++) intensity for FasL staining; all of these were moderately or poorly differentiated. Conclusions Fas was expressed more strongly in well‐differentiated SCCs than in poorly differentiated tumors. FasL was expressed more strongly in moderately and poorly differentiated tumors. These findings indicate that Fas and FasL play important roles in immune surveillance and grade of differentiation in SCC.