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Atopic dermatitis: correlation between non‐damaged skin barrier function and disease activity
Author(s) -
Addor Flavia A.S.,
Takaoka Roberto,
Rivitti Evandro A.,
Aoki Valeria
Publication year - 2012
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2011.05176.x
Subject(s) - transepidermal water loss , atopic dermatitis , medicine , dermatology , severity of illness , correlation , positive correlation , atopy , immunoglobulin e , barrier function , pathology , immunology , immunopathology , stratum corneum , mathematical optimization , geometry , mathematics , antibody
Background Atopic dermatitis (AD) is a chronic dermatosis, predominant in childhood, characterized by pruritus and eczematous‐type lesions with xerosis as the prominent clinical sign. Objectives To analyze the correlation between biophysical measurements of skin barrier function and other assessment criteria of clinical severity according to Rajka and Langeland’s criteria. Methods Biophysical measurements [transepidermal water loss (TEWL) and corneometry] were obtained from 120 patients with the diagnosis of AD. Serum levels of IgE were also evaluated. Results A significant correlation between corneometry, TEWL, and clinical severity of AD was found. Data showed an inverse correlation between corneometry, TEWL, and AD severity, and a significant difference ( P < 0.001) between mean of corneometry and TEWL and AD severity (mild, moderate, and severe). As for IgE levels, corneometry had significant negative correlation, in contrast with TEWL, which showed a significant positive correlation ( P < 0.001). Conclusion Biophysical measurements of skin barrier in non‐lesional skin of AD may work as an evaluation factor for AD severity.