Premium
Prolactin level is significantly elevated in lesional skin of patients with psoriasis
Author(s) -
ElKhateeb Ekramy A.,
ZuelFakkar Nehal M.,
Eid Safaa M.,
AbdulWahab Soha E.
Publication year - 2011
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2010.04752.x
Subject(s) - psoriasis , medicine , pathogenesis , prolactin , psoriasis area and severity index , gastroenterology , dermatology , endocrinology , pathology , hormone
Background Accumulating data point to a potential role of prolactin in the pathogenesis of psoriasis. Methods We initiated a study including psoriasis patients ( n = 15) and healthy volunteers ( n = 15) as controls. Psoriasis area and severity index (PASI) score was evaluated, and prolactin levels in serum and blister fluid were assessed by enzyme‐linked immunosorbent assay (ELISA). Results Prolactin levels were significantly ( P < 0.01) elevated in blister fluid of psoriatic lesional skin. Correlations between PASI score and different serum prolactin levels in lesional and non‐lesional skin were insignificant. Significant positive correlations of prolactin level were observed between lesional and non‐lesional skin in psoriasis ( P < 0.05) and between serum and clinically normal skin in both psoriasis and control subjects ( P < 0.05). Conclusions Locally produced prolactin may be involved in the pathogenesis of psoriatic lesions.