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Leishmaniasis recidivans among school children in Bam, South‐east Iran, 1994–2006
Author(s) -
Sharifi Iraj,
Fekri Ali Reza,
Aflatoonian Mohammad Reza,
Khamesipour Ali,
Mahboudi Fereidoun,
Dowlati Yahya,
Nadim Abolhassan,
Modabber Farrokh
Publication year - 2010
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2010.04419.x
Subject(s) - medicine , cutaneous leishmaniasis , leishmaniasis , amastigote , histology , polymerase chain reaction , dermatology , pathology , leishmania , biology , gene , computer science , parasite hosting , biochemistry , world wide web
Background Leishmaniasis recidivans (LR) is a rare phenomenon in the world with high morbidity in children. Methods Overall 22 838 school children were examined during 1994–2006. Diagnosis was performed by combination of methods as clinical appearance, direct smears, cultures, polymerase chain reaction (PCR) and histology. Results Ninety‐eight cases were diagnosed as LR with duration of lesions varying from 2 to 8 years and diameter of lesions 1–5 cm, yellowish‐brown appearance with papules around or in the scar. Most of the lesions (95%) were on the face. No amastigote was found in direct smears. Identification of nine random isolates by PCR confirmed all species to be L. tropica . Tissue sections showed typical granulomatous reactions with various inflammatory cells but no visible amastigote was seen. Conclusions The presence of LR as an important cause of morbidity has future implications for treatment regimens and immunoprophylaxis.