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Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors
Author(s) -
Habib Nancy,
Salaro Cristina,
AlGhaithi Khalid,
Phelps Robert G.,
Saggar Sarika,
Cohen Steven R.
Publication year - 2010
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2009.04319.x
Subject(s) - medicine , tacrolimus , sirolimus , calcineurin , stomatitis , dermatology , mucocutaneous zone , recurrent aphthous stomatitis , complication , population , surgery , transplantation , disease , environmental health
Background Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy. This association has been reported less frequently with tacrolimus. Case We present an 11‐year old male with Budd‐Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus. Conclusion Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.