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Glucagonoma syndrome and necrolytic migratory erythema
Author(s) -
Lobo Inês,
Carvalho André,
Amaral Cláudia,
Machado Susana,
Carvalho Rui
Publication year - 2010
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2009.04220.x
Subject(s) - glucagonoma , medicine , pancreas , anemia , glucagon , diabetes mellitus , weight loss , pancreatic disease , dermatology , alpha cell , endocrine system , erythema , glycemic , gastroenterology , endocrinology , pathology , insulin , hormone , beta cell , obesity , islet
The glucagonoma syndrome is a rare disorder, characterized by necrolytic migratory erythema, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia in association with a glucagon‐secreting alpha‐cell tumor of the pancreas. We present a 67‐year‐old diabetic patient with extensive cutaneous lesions, weight loss, and poor glycemic control. The clinical investigation revealed a pancreatic glucagonoma with resolution of the cutaneous and systemic features after surgical removal. The dermatologic and endocrine approach to this syndrome is discussed here. Early recognition and treatment may prevent metastatic disease and ensure its cure with resolution of the cutaneous and catabolic manifestations.