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Amoxicillin–clavulanic acid‐induced linear immunoglobulin A bullous dermatosis: case report and review of the literature
Author(s) -
Panasiti Vincenzo,
Rossi Mariarita,
Devirgiliis Valeria,
Curzio Michela,
Bottoni Ugo,
Calvieri Stefano
Publication year - 2009
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2009.04104.x
Subject(s) - medicine , dapsone , amoxicillin , dermatology , clavulanic acid , autoimmune disease , antibody , immunology , antibiotics , microbiology and biotechnology , biology
Background Linear immunoglobulin A bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease, rarely induced by drugs. Methods We describe a case of a 47‐year‐old man who developed a severe blistering eruption after therapy with amoxicillin–clavulanic acid. Results Histopathologic examination and direct immunofluorescence were consistent with a diagnosis of LABD. Therapy with dapsone controlled the disease but, after sun exposure, there was a worsening of the illness. Conclusion To our knowledge, this is the first case of amoxicillin–clavulanic acid‐induced LABD in an adult.