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Bcl‐2 and CD10 expression in the differential diagnosis of trichoblastoma, basal cell carcinoma, and basal cell carcinoma with follicular differentiation
Author(s) -
Córdoba Alicia,
Guerrero David,
Larrinaga Begoña,
Iglesias Maria Eugenia,
Arrechea Maria Asunción,
Yanguas Juan Ignacio
Publication year - 2009
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2009.04076.x
Subject(s) - basal cell carcinoma , pathology , immunohistochemistry , stromal cell , follicular phase , differential diagnosis , carcinoma , medicine , stroma , basal (medicine) , staining , trichoepithelioma , biology , basal cell , insulin
Background Both trichoblastoma and basal cell carcinoma (BCC) of the skin are characterized morphologically by the proliferation of basaloid cells; however, BCCs are clinically associated with a more aggressive behavior. An accurate diagnosis of these lesions is essential for effective, timely treatment and appropriate therapeutic decisions. Methods This study includes 40 lesions. Bcl‐2 and CD10 immunohistochemistry were performed in all cases and the patterns of expression were analyzed. Results Bcl‐2 is useful for the detection of BCC with diffuse expression in nests of basaloid cells, but cannot distinguish between BCC with follicular differentiation and trichoblastoma, as both lesions show the same pattern with positive and negative areas. Conversely, CD10 expression can distinguish between trichoblastomas with peritumoral stromal staining and BCCs with epithelial staining. If both stromal and epithelial areas are stained, these cases are classified as BCC with follicular differentiation. Conclusions CD10 is useful for distinguishing between BCC with widespread follicular differentiation and trichoblastomas.