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Association of serotonin transporter gene‐linked polymorphic region and variable number of tandem repeat polymorphism of the serotonin transporter gene in lichen simplex chronicus patients with psychiatric status
Author(s) -
Kirtak Necmettin,
Inaloz H. Serhat,
Akçali Cenk,
Erdal Emin,
Herken Hasan,
Yildirim Mehmet,
Erguven H. Gulcin
Publication year - 2008
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2008.03821.x
Subject(s) - serotonin transporter , genotype , serotonergic , variable number tandem repeat , gene polymorphism , serotonin , polymorphism (computer science) , biology , medicine , genetics , endocrinology , gene , receptor
Background The serotonin (5‐hydroxytryptamine; 5‐HT) is a key neurotransmitter in the central nervous system and a responsible mediator for the itch. Dysregulation of serotonergic pathways has been implicated in the pathogenesis of many complex neuropsychiatric diseases. Objectives The purpose of this study was to evaluate the relationship between lichen simplex chronicus and dysfunction and serotonin transporter (5‐HTT) gene polymorphism. Methods Thirty‐nine patients with lichen simplex chronicus and 61 healthy control subjects were examined. Results The results for the patients and control subjects were not significantly different ( P > 0.05) in long/long (L/L) and long/short (L/S) genotypes of 5‐HTT gene‐linked polymorphic region (HTTLPR) polymorphism, but short/short S/S genotype was lower in lichen simplex chronicus patients (17.9%) than in controls (42.6%). This difference was statistically significant ( P = 0.028). The results for the patients and control subjects were not significantly different in 12/12, 10/12 and 10/10 genotypes of variable number of tandem repeat (VNTR) polymorphism ( P > 0.05). Beck depression inventory (BDI) scores and symptom checklist‐90‐revised (SCL‐90) psychotic subscale were overrepresented significantly in the 12/12 genotypes than 10/12 genotypes. State and Trait Anxiety Inventory tests (STAI‐I and ‐II) point averages were not statistically significant ( P > 0.05) Conclusion S/S genotypes of HTTLPR polymorphism in the 5‐HTT gene may be related to lichen simplex chronicus and that patients who have 12/12 genotypes of VNTR polymorphism may be affected psychiatrically.