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Pyoderma gangrenosum following isotretinoin therapy for acne nodulocystic
Author(s) -
Paula Tinoco Maria,
Tamler Carla,
Maciel Gustavo,
Soares Deborah,
Carlos Avelleira João,
Azulay David
Publication year - 2008
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2008.03662.x
Subject(s) - medicine , pyoderma gangrenosum , isotretinoin , dermatology , acne , disease
A 19‐year‐old man with nodulocystic acne on baseline was treated with isotretinoin therapy. After 1 month on the medication, he developed pyoderma gangrenosum on his pubis area, arms and legs, and pathergy on a puncture site. Possible underlying diseases were excluded. The patient was started on steroids (prednisone 1 mg/kg/d) and isotretinoin therapy was withdrawn. Later the prednisone was tappered and dapsone 100 mg/daily was initiated. After 10 months of follow‐up all lesions had healed and no underlying diseases developed.