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Acrodermatitis enteropathica in a full‐term breast‐fed infant: case report and literature review
Author(s) -
Azevedo Patrícia Mesquita Couto,
GavazzoniDias Maria Fernanda Reis,
Avelleira João Carlos Regazzi,
Lerer Cláudio,
De Sousa Aline Soares,
Azulay David Rubem
Publication year - 2008
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2008.03626.x
Subject(s) - acrodermatitis enteropathica , medicine , nose , dermatology , breast feeding , surgery , zinc deficiency (plant disorder) , pediatrics , pathology , micronutrient
A male full‐term infant, who had been exclusively breast‐fed since birth, at 2 months of age developed an erythematous, scaling eruption involving the face (in a periorificial distribution, i.e. mouth, nose, ears, and eyes), hands, and feet, which did not respond to treatment with topical corticosteroids and oral antimicrobials. He was first seen at our institution at 5 months of age ( Figs 1 and 2). He had been irritable for the last 2 weeks, but had no diarrhea, alopecia, or anogenital lesions. A clinical diagnosis of acrodermatitis enteropathica was confirmed with a serum zinc level of 41.2 µg/dL (normal, 70–120 µg/dL). His mother had low–normal serum (70.5 µg/dL; normal, 70–120 µg/dL) and normal milk (0.43 µg/mL; normal, 0.2–0.72 µg/mL) zinc concentrations. Within 7 days of starting therapy with zinc sulfate, 10 mg/kg/day, all cutaneous lesions had resolved ( Fig. 3). 1Infant at 5 months of age showing an erythematous, scaling eruption involving the face (periorificial distribution, i.e. mouth, nose, and eyes) and hands2Infant with dermatophytosis‐like lesions3Infant at 6 months of age after starting oral zinc supplementation. The lesions have resolved