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Metabolic syndrome associated with toenail onychomycosis in Taiwanese with diabetes mellitus
Author(s) -
Chang ShunJen,
Hsu ShihChieh,
Tien KaiJen,
Hsiao JengYueh,
Lin ShiuRu,
Chen HungChun,
Hsieh MingChia
Publication year - 2008
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2008.03606.x
Subject(s) - medicine , glycemic , diabetes mellitus , metabolic syndrome , obesity , triglyceride , complication , endocrinology , cholesterol
Background Onychomycosis is a complication of diabetes mellitus (DM), which has a deleterious impact on the quality of life. Aim To explore the prevalence of onychomycosis amongst Taiwanese diabetics, and to analyze the factors associated with onychomycosis after adjusting for age and sex. Methods A total of 1245 Taiwanese diabetics were enrolled, and a nested case–control study was performed by onychomycosis outcome and the exposures were compared. Results The overall prevalence of onychomycosis among DM patients was 30.76% (383/1245), with a significantly higher prevalence in men than in women ( P = 0.024). The factors associated with onychomycosis in matched pairs by gender and age were analyzed in 375 pairs. It was found that metabolic syndrome, obesity, triglyceride (TG) levels, and glycosylated hemoglobin (HbA1c) were associated with onychomycosis ( P < 0.05). Conclusion Higher prevalence rates of onychomycosis were found in men and older DM patients. Metabolic syndrome, obesity, high TG levels, and poor glycemic control were associated with onychomycosis.