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Porphyria cutanea tarda in pre‐existent lupus erythematosus – is there an association?
Author(s) -
Van Tuyll van Serooskerken AnneMoon,
Habets J. M. Werner,
Badeloe Sadhanna,
PobleteGutiérrez Pamela,
Frank Jorge
Publication year - 2007
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2007.03515.x
Subject(s) - medicine , porphyria cutanea tarda , dermatology , milia , erythema multiforme , uroporphyrinogen iii decarboxylase , bullous pemphigoid , lupus erythematosus , pemphigus , dermatitis herpetiformis , vitiligo , hypertrichosis , toxic epidermal necrolysis , porphyria , pathology , immunology , disease , heme , biochemistry , chemistry , antibody , enzyme
In lupus erythematosus (LE), vesicles and bullae are only rarely seen. However, in some instances such efflorescences might suggest an association with distinct cutaneous diseases, including erythema multiforme, toxic epidermal necrolysis or autoimmune blistering disorders such as bullous pemphigoid, pemphigus vulgaris, and dermatitis herpetiformis Duhring. Another blistering disease that has been described in association with cutaneous and systemic LE is porphyria cutanea tarda (PCT). PCT is a metabolic disorder caused by a deficiency of the fifth enzyme in heme biosynthesis, uroporphyrinogen decarboxylase. Here, we report on a 57‐year‐old Caucasian woman of Dutch origin with a medical history of mild cutaneous LE who developed skin fragility, blistering skin lesions, milia, and facial hypertrichosis. Subsequent porphyrin analysis in urine and feces confirmed the suspected simultaneous manifestation of LE and PCT.