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Porphyria cutanea tarda as rare cutaneous manifestation of hepatic metastases treated with interferon
Author(s) -
Mosterd Klara,
Henquet Charles,
Frank Jorge
Publication year - 2007
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2007.03504.x
Subject(s) - porphyria cutanea tarda , medicine , hexachlorobenzene , interferon , hereditary hemochromatosis , gastroenterology , hemochromatosis , dermatology , metastasis , pathology , immunology , cancer , chemistry , organic chemistry , pollutant
A 53‐year‐old woman with blistering on the hands was diagnosed with porphyria cutanea tarda (PCT). At that time, she was treated with interferon for liver metastasis of a pancreas tumor since 7 years. Although apparently rare, PCT has been described as possible cutaneous manifestation both of hepatic tumors and interferon treatment. Further, PCT can also be exacerbated by hepatitis C virus infection, alcohol, estrogens, HFE gene mutations predisposing for hereditary hemochromatosis, hexachlorobenzene, and 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin. Therefore, it is important to keep in mind that the manifestation of PCT may be associated with distinct precipitating factors, which are briefly discussed here.