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Chemotherapeutic/chemopreventive role of retinoids in chemically induced skin carcinogenesis in albino mice
Author(s) -
Bukhari Mulazim H.,
Qureshi Shahzad Shafqat,
Niazi Shahida,
Asef Mohammad,
Naheed Mamona,
Khan Saeed A.,
Chaudhry Naseer A.,
Tayyab Mohammad,
Hasan Mumtaz
Publication year - 2007
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2007.03425.x
Subject(s) - dmba , medicine , carcinogenesis , lesion , retinoid , skin tumours , skin lesion , chemotherapy , pathology , cancer , biology , retinoic acid , biochemistry , gene
Objective To determine the chemotherapeutic effect of retinoids on albino mouse skin. Methods Eighty albino mice were selected for this study and were divided into four groups (A–D, 20 mice in each group). 7,12‐Dimethylbenz(a)anthracene (DMBA) and tetradecanoylphorbal‐13‐acetate (TPA) were given for 15 weeks to produce tumors. Retinoids were given topically and orally after the development of tumors for the following 15 weeks. Results Of the 80 mice, 69 (86.25%) developed different types of lesion and 11 (13.75%) remained lesion free. Of the 69 mice that developed lesions, 50 (62.50%) developed benign lesions and 19 (23.75%) developed malignant lesions. In all groups of mice, treatment with retinoids was effective against all benign lesions and the early stages of carcinogenesis of the skin. The chemotherapeutic effect against malignant tumors was not satisfactory. Conclusion This study demonstrates that retinoids are effective as chemopreventive agents in premalignant lesions of the skin, but have a very weak chemotherapeutic role in malignant neoplasms. If retinoids are given at an early stage, they can cause regression of premalignant lesions of the skin. They are best administered both orally and parenterally. These agents should be recommended as they reduce the potential effects of carcinogenesis.