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An unusual presentation of human papillomavirus (HPV) infection in a black epidermodysplasia verruciformis (EV) patient
Author(s) -
Sanclemente Gloria,
García JoséJ.,
Gómez LuisF.,
Tyring Stephen K.,
Wolff Juan C.,
Correa Luis A.,
Rady Peter
Publication year - 2007
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2006.03083.x
Subject(s) - epidermodysplasia verruciformis , medicine , human papillomavirus , presentation (obstetrics) , virology , dermatology , surgery
A 25‐year‐old black man had a 20‐year history of disseminated plaques on his body. Two years before consultation he noticed several tumors on the genitalia. Physical examination revealed generalized, coalescing, hypopigmented plaques with a very defined and keratotic border that resembled actinic porokeratosis. ( Fig. 1). Multiple verrucous and moist tumors were observed on the scrotum ( Fig. 2). His past medical history was unremarkable, and no family member had the disease. 1Generalized, coalescing, hypopigmented plaques2Multiple verrucous and moist tumors on the scrotum Histology of the body lesions revealed hyperkeratosis with a horny‐layer, basket‐weave appearance, large and clear blue–gray keratinocytes with finely granular cytoplasm and vacuolized nuclei, and abundant keratohyaline granules located in the upper epidermal layer ( Fig. 3). Scrotum biopsy showed hyperkeratosis, irregular acanthosis with papillomatosis, and koilocytic figures. 3Hyperkeratosis with basket‐weave appearance of the horny layer and vacuolated blue–gray keratinocytes (hematoxylin and eosin stain, ×20) The genital lesions were treated with monthly cryotherapy plus surgical excision with complete disappearance of the lesions. A decrease in ultraviolet exposure and daily sun‐block were encouraged for epidermodysplasia verruciformis lesions. After genital wart clearance, follow‐ups are being scheduled every 4 months, with no new lesions to date.