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Clinical, histologic and immunologic features of pemphigus in Bangladesh
Author(s) -
Amin Md. Nurul,
Islam A. Z. M. Maidul
Publication year - 2006
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2006.02942.x
Subject(s) - pemphigus vulgaris , pemphigus , medicine , iif , direct fluorescent antibody , pathology , antibody , titer , dermatology , indirect immunofluorescence , immunology
We studied the clinical, histologic and immunologic features of 32 pemphigus patients evaluated in Dhaka. The diagnosis was pemphigus vulgaris (PV) in 72% of cases, and pemphigus foliaceous (PF) in 28%, with male to female ratios of 1.3 : 1 and 1.25 : 1, respectively. Only 25% of PV patients had vesicles or bullae involving mucous membranes as the initial presentation. Direct (DIF) and indirect (IIF) immunofluorescence tests were positive in all 32 patients. The DIF testing of tissue demonstrated intercellular substance (ICS) deposition of IgG (59%) or IgG plus C3 (41%). Serum ICS antibody titers ranged from 1 : 20–40 in PV and from 1 : 10–20 in patients with PF. To our knowledge, this is the first report concerning the characteristics of pemphigus in Bangladesh.