Premium
Crystal storing histiocytosis of the skin associated with multiple myeloma
Author(s) -
Pock Lumír,
Stuchlík David,
Hercogová Jana
Publication year - 2006
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2006.02919.x
Subject(s) - medicine , histiocyte , pathology , histiocytosis , malignant histiocytosis , multiple myeloma , malignancy , biopsy , skin biopsy , differential diagnosis , lymphoma , dermatology , disease
Background Crystal storing histiocytosis (CSH) imitating rhabdomyom is a very rare disease entity involving different tissues. The skin is involved in extremely rare cases. Objectives To describe the clinical and histopathological characteristics in a patient with unusually extensive skin involvement. Observations A 62‐year‐old woman presented with a large red infiltrated verrucosus lesion on the anterior aspect of the chest and on the neck. The skin biopsy revealed histiocytes throughout the whole dermis containing thin crystaloid structures in the cytoplasm. Upon histopathological examination, crystal‐storing histiocytosis was diagnosed and consequently a hematological examination revealed multiple myeloma IgG Kappa. Skin involvement by CSH proceeded the diagnosis of multiple myeloma by 4 years. Conclusions Phagocytosis of crystals of immunoglobulins by histiocytes (crystals storing histiocytosis) is a rare symptom associated most often with lymphoproliferative disease. The clinical picture is not characteristic, in the histopathologic picture it is striking similarity to rhabdomyom. The skin involvement by crystal storing histiocytosis can be the first symptom of malignant lymphoma that can proceed the hematological malignancy by years.