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Genetic epidemiology of vitiligo: a study of 815 probands and their families from south China
Author(s) -
Sun Xiukun,
Xu Aie,
Wei Xiaodong,
Ouyang Jie,
Lu Liangjun,
Chen Meihua,
Zhang Dimin
Publication year - 2006
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2006.02907.x
Subject(s) - vitiligo , medicine , proband , epidemiology , china , genetic epidemiology , genetics , dermatology , mutation , gene , biology , political science , law
Background Genetic factors are thought to be involved in the development of vitiligo. Aim To explore the possible genetic model of vitiligo by analyzing the genetic characteristics of 815 patients and their families from south China (Zhejiang Province). Methods Data for 815 patients with vitiligo were obtained by questionnaire. The inheritance pattern estimation, heritability calculation, and complex segregation analysis were performed using the Penrose method, Falconer regression method, and SAGE‐REGTL program, respectively. Results In 815 vitiligo probands, 128 (15.7%) had a family history. The ratio of the sibling prevalence rate to the population prevalence rate ( s / q ) approached 1/using the Penrose calculation, and the heritability degrees of vitiligo in the first‐ and second‐degree relatives were 59.6% and 55.2%, respectively. The complex segregation analysis suggested that the dominant model was the best‐fit genetic model for vitiligo. Conclusions Genetic factors play an important role in the occurrence of vitiligo, and the genetic model of vitiligo in this population is consistent with a polygenetic or multifactorial inheritance in a dominant major gene pattern.