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Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report
Author(s) -
Zerpa Olga,
Blanco Belkys,
Kannee Carmen,
Ulrich Marian,
Sindermann Herbert,
Engel Juergen,
Convit Jacinto
Publication year - 2006
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2006.02751.x
Subject(s) - miltefosine , medicine , leishmaniasis , cutaneous leishmaniasis , dermatology , adverse effect , psychosocial , surgery , infiltration (hvac) , visceral leishmaniasis , pathology , thermodynamics , physics , psychiatry
Background A 31‐year‐old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine. Methods The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently. Results Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed. Conclusions The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.