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Neutrophilic eccrine hidradenitis in non‐small cell lung cancer
Author(s) -
Lee Seung Gyu,
In Seung Gyun,
Shin Jeong Hyun,
Choi Gwang Seong,
Kim Yoo Chan
Publication year - 2007
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2006.02606.x
Subject(s) - medicine , h&e stain , pathology , skin biopsy , chemotherapy , biopsy , dermis , lung cancer , surgery , staining
A 75‐year‐old man was treated for non‐small cell lung cancer (NSCLC) (stage IIIb) with three‐cycle chemotherapy (cisplatin and paclitaxel) for 3 weeks. No skin lesions were observed during the first and second chemotherapy cycles. After the third chemotherapy cycle, he developed slightly pruritic skin eruptions on the anterior chest. He was treated for 1 month with topical steroid without improvement, and was referred to our dermatologic department. Skin examination revealed slightly elevated, dusky, erythematous, edematous patches on the anterior chest in a bilateral distribution ( Fig. 1). 1Dusky, erythematous, edematous patches on the anterior chest Histologic examination of a biopsy specimen taken from the cutaneous lesions showed a neutrophilic infiltrate surrounding the secretory eccrine glands. The epithelial cells of the eccrine ducts and coils were not affected. There was a mild superficial perivascular infiltrate of mainly lymphocytes. These changes were consistent with a diagnosis of neutrophilic eccrine hidradenitis ( Fig. 2). 2An inflammatory infiltrate involving eccrine coils in the dermis without vasculitis (hematoxylin and eosin, ×40). Inset: neutrophils surrounding eccrine coils (hematoxylin and eosin, ×400) He was treated with dapsone, 50 mg/day, and methylprednisolone, 8 mg/day, for 2 weeks, and his skin lesions improved. Two months later the erythematous eruptions recurred on the chest, back, and extremities without the use of any chemotherapeutic agent, and were treated effectively with the same drugs.