Premium
A case of pemphigus vulgaris accompanied by multiple myeloma
Author(s) -
Kurokawa Motoki,
Koketsu Hideki,
Oda Yujiro,
Nagamine Hidehiro,
Toyama Takanori,
Hashimoto Takashi,
Setoyama Mitsuru
Publication year - 2005
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2005.02248.x
Subject(s) - pemphigus vulgaris , desmoglein 3 , medicine , paraneoplastic pemphigus , acantholysis , pemphigus , mucocutaneous zone , multiple myeloma , autoantibody , pathology , desmoglein 1 , dermatology , desmoglein , immunology , disease , antibody
Pemphigus is a mucocutaneous intraepithelial blistering disease caused by autoantibodies to epithelial cell adhesion molecules (desmoglein). The association between pemphigus and malignant neoplasm is well recognized. We present the case of a 62‐year‐old woman with pemphigus vulgaris accompanied by multiple myeloma. To the best of our knowledge, this is the first report of a case of pemphigus vulgaris concomitant with multiple myeloma. From the results of immunoblotting using normal human epidermal extracts and indirect immunofluorescence using rat bladder sections, and her clinical manifestations, our case does not seem to be one of paraneoplastic pemphigus.