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Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations
Author(s) -
Masala Maria Vittoria,
Carcassi Carlo,
Cottoni Francesca,
Mulargia Marina,
Contu Licinio,
Cerimele Decio
Publication year - 2005
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02206.x
Subject(s) - medicine , incidence (geometry) , genetic predisposition , human leukocyte antigen , sarcoma , immunology , disease , antigen , pathology , physics , optics
Background The incidence of classic Kaposi's sarcoma (CKS) in northern Sardinia is one of the highest in the world. Methods Sixty‐two patients with CKS were typed for class I and class II antigens. All patients had been born and were living in northern Sardinia. Results In the Sardinian patients, we observed a positive CKS association with Cw7, DRB1*1104, DRB1*1302, DQA1*0302, and DQB1*0604, and a negative CKS association with A30, B58, Cw5, DRB1*1601, and DQB1*0502. Conclusions The strong positive CKS association with DRB1*1104 and DQB1*0604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.