Premium
Immunohistochemical study of serotonin in lesions of psoriasis
Author(s) -
Huang Jianguo,
Li Guiming,
Xiang Jihu,
Yin Daochun,
Chi Ridong
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02195.x
Subject(s) - psoriasis , serotonin , pathogenesis , sweat gland , immunohistochemistry , medicine , pathology , dermatology , sweat , receptor
Objective To study the role of serotonin in the pathogenesis of psoriasis. Methods Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with psoriasis. Results Expression of serotonin was significantly stronger in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in the progressive stage of psoriasis than in the static stage. There was no difference in serotonin expression between the vulgaris type and the pustular type. No expression of serotonin occurred in the specimens of normal skin. Conclusion Serotonin probably plays an important role in the pathogenesis and activity of psoriasis.