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Additional conjunctival and penile pigmentation in Laugier–Hunziker syndrome: a report of two cases
Author(s) -
Ayoub Nakhlé,
Barete Stéphane,
Bouaziz JeanDavid,
Pelletier François Le,
Frances Camille
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02173.x
Subject(s) - medicine , hyperpigmentation , melanosis , dermatology , oral mucosa , pigmentation disorder , acanthosis , conjunctiva , pathology , anatomy , hyperkeratosis , melanoma , cancer research
Background Laugier–Hunziker syndrome is a rare acquired hyperpigmentation of the oral mucosa and lips which is often associated with longitudinal melanonychia. We report two patients exhibiting the classical features of Laugier–Hunziker syndrome with additional and previously unreported conjunctival and penile pigmentation. Patients and methods Two patients presented with a history of progressive acquired macular pigmentation of the oral mucosa, the lips, the ocular conjunctiva and the penis. Longitudinal melanonychia was found in one patient. Microscopic features (basal epithelial melanosis, moderate acanthosis and superficial pigmentary incontinence) and ultrastructural details (increased number of normal‐appearing melanosomes inside basal keratinocytes and dermal melanophages) were characteristic of Laugier–Hunziker syndrome. Conclusions These two observations illustrate the topographical variations of Laugier–Hunziker syndrome and highlight the need to expand the originally described features to include more widespread areas of hyperpigmentation.