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Insect bite‐like reaction associated with mantle cell lymphoma: a report of two cases and review of the literature
Author(s) -
DodiukGad Roni P.,
Dann Eldad J.,
Bergman Reuven
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02145.x
Subject(s) - medicine , mantle cell lymphoma , lymphoma , mantle (geology) , dermatology , pathology , paleontology , geology
Background An insect bite‐like reaction and exaggerated reactions to insect bites are nonspecific phenomena described primarily in association with chronic lymphocytic leukemia (CLL), but also with other hematological malignancies. Two cases of mantle cell lymphoma (MCL), one associated with an insect bite‐like reaction and the other with a true hypersensitivity to mosquito bites, have previously been reported in the English language literature. The pathogenesis of the skin eruption may be related to the release of different cytokines that also trigger an IgE elevation and dermal eosinophils. Case report We describe two additional cases of MCL associated with an insect bite‐like reaction. One patient had been diagnosed with MCL 4.5 years prior to the appearance of the skin eruption, and in the other patient the skin symptoms preceded the diagnosis of the MCL by 2 years and led to its diagnosis. Conclusions Insect bite‐like reaction may appear in patients with MCL. It is important to recognize this entity because it may be the presenting sign of MCL.