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A case of human insulin allergy induced by short‐acting and intermediate‐acting insulin but not by long‐acting insulin
Author(s) -
Adachi Atsuko,
Fukunaga Atsushi,
Horikawa Tatsuya
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02141.x
Subject(s) - insulin , medicine , human insulin , histamine , insulin aspart , endocrinology , diabetes mellitus , allergy , insulin lispro , urticaria pigmentosa , immunology , hypoglycemia
A 66‐year‐old woman suffering from pollinosis developed generalized urticaria after injection of intermediate‐acting insulin for diabetes mellitus. She had human insulin‐specific IgE, and in skin tests was positive for human recombinant insulin and negative for additives. Uniquely, she reacted to fast‐acting and slow‐acting insulin but not to long‐acting insulin. We further confirmed that human insulin preparations could stimulate her peripheral basophils to release a significant amount of histamine. Genetically generated human insulin analogs, aspart and lispro, induced positive skin tests and histamine release from basophils. She was recommended to use a long‐acting insulin preparation and was free from symptoms thereafter.