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Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to Helicobacter pylori
Author(s) -
Baz Kiymet,
Cimen M. Y. Burak,
Kokturk Aysin,
Aslan Gonul,
Ikizoglu Guliz,
Demirseren D. Deniz,
Kanik Arzu,
Atik Ugur
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02137.x
Subject(s) - rosacea , helicobacter pylori , oxidative stress , medicine , malondialdehyde , reactive oxygen species , immunology , ascorbic acid , antioxidant , gastroenterology , antibody , biology , biochemistry , dermatology , food science , acne
Background Recent studies have suggested that there might be an etiologic role for Helicobacter pylori (HP) in rosacea. HP is a Gram‐negative bacterium that colonizes the gastric mucosa, increases the generation of reactive oxygen species (ROS), and decreases plasma antioxidants such as ascorbic acid. Aim To investigate plasma ROS activities and antioxidant status, and their relationship with HP infection, in rosacea patients. Methods Twenty‐nine rosacea patients and 20 age‐ and sex‐matched healthy controls were examined for specific immunoglobulin G (IgG) and IgM against HP, plasma malondialdehyde (MDA), and antioxidant potential (AOP) levels. Results Compared with controls, the seropositivity of HP for IgM was significantly higher ( P = 0.03) and the seropositivity of HP for IgG was significantly lower ( P = 0.0001) in patients with rosacea. Plasma MDA levels were higher ( P = 0.0001) and AOP levels were lower ( P = 0.019) in patients than in controls, regardless of the severity of the disease. Plasma MDA and AOP levels were not affected by the seropositivity of HP for IgM and/or IgG in either group. Conclusion Our results suggest that rosacea is an oxidative stress condition, as reflected by the increased ROS activity and decreased AOP, regardless of HP infection.