Disseminated granuloma faciale

A 40‐year‐old man presented in January 2001 with multiple purple plaques and nodules, which had been present on the back for approximately 3 years. The lesions had gradually extended over the face, trunk and proximal extremities. He had no symptoms except occasional mild pruritus. The patient was in good health and was on no medications. Physical examination revealed multiple violaceous to brown, indurated, 5–50‐mm, round to oval plaques on the face, arms, shoulders, and back ( Fig. 1), as well as a solitary lesion on the right thigh. Surface telangiectases were noted, especially on the shoulder lesions. There was no scaling or ulceration. Routine laboratory tests were unremarkable. 1Multiple reddish‐brown plaques on the back In April 1999, another medical center performed a biopsy of what they thought was sarcoidosis. The results were reported as “possible angiolymphoid hyperplasia with eosinophilia.” With the possibility of granuoma faciale (GF) in mind, another skin biopsy was obtained from a facial lesion. This revealed a diffuse, relatively dense infiltrate of neutrophils, eosinophils and mononuclear inflammatory cells in dermis with an obvious Grenz zone ( Fig. 2). Pilar units were intact, and endothelial cell swelling was present ( Fig. 3). Retrospective evaluation of the initial biopsy, taken from the back, revealed the same changes, and helped confirm the diagnosis of GF. 2A diffuse, relatively dense mixed infiltrate, separated from a normal epidermis by a Grenz zone (hematoxylin and eosin, × 40)3Polymorphous infiltrate containing eosinophils, neutrophils, and lymphocytes surrounding dilated dermal vessels with swollen endothelial cells (hematoxylin and eosin, × 400) The patient was treated with liquid nitrogen for 20 s followed immediately by intralesional triamcinolone acetonide (5 mg/ml). This treatment was repeated every 4 weeks for three courses, resulting in partial resolution of the lesions.