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HLA‐DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han
Author(s) -
Zhang Xuejun,
Wei Shengcai,
Yang Sen,
Wang Zaixing,
Zhang Anping,
He Pingping,
Wang Hongyan
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02098.x
Subject(s) - psoriasis , allele , human leukocyte antigen , locus (genetics) , genetic predisposition , pathogenesis , immunology , medicine , biology , genetics , antigen , gene
Background Psoriasis vulgaris is a chronic skin disorder characterized by infiltration of inflammatory elements, keratinocyte hyperproliferation and altered differentiation. Although the pathogenesis of psoriasis is not fully understood, there is solid evidence of a susceptibility locus in the human leukocyte antigen (HLA) region. Objectives To investigate whether HLA‐DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han. Patients and methods The polymerase chain reaction–sequence‐specific primer (PCR‐SSP) method was used to analyse the distribution of HLA‐DQA1 and DQB1 alleles in 189 patients with psoriasis and 273 healthy controls. Results The HLA‐DQA1*0104 (OR = 2.33, P = 0.0001154, P c = 2.0 × 10 −3 ), DQA1*0201 (OR = 3.36, P < 1.0 × 10 −7 , P c < 1.0 × 10 −6 ), DQB1*0201 (OR = 1.64, P = 0.0192, P c > 0.05) and DQB1*0303 (OR = 1.55, P = 0.0377, P c > 0.05) alleles were more prevalent in patients with psoriasis vulgaris than in controls, and HLA‐DQA1*0501 (OR = 0.30, P = 0.39, P c < 4.0 × 10 −5 ) alleles were less prevalent. The HLA‐DQA1*0104 (OR = 2.42, P = 0.0001159, P c < 2.0 × 10 −3 ), DQA1*0201 (OR = 3.74, P < 1.0 × 10 −7 , P c < 1.0 × 10 −6 ) and DQA1*0501 (OR = 0.30, P = 0.0000374, P c < 4.0 × 10 −4 ) alleles were only associated with type I psoriasis. HLA‐DQA1*0104 and DQA1*0201 were more prevalent in patients with or without a family history of psoriasis. However, the DQA1*0501 allele was only more prevalent in patients without a family history of psoriasis. Conclusion HLA‐DQA1*0104 and DQA1*0201 alleles may be psoriasis susceptibility genes or may be in close linkage with the susceptibility genes. The HLA‐DQA1*0501 allele seems to have a protective effect against the development of psoriasis vulgaris in Chinese Han. There may be a difference in genetic background between psoriasis patients with and without a family history of psoriasis.