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Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: A review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual
Author(s) -
Shapiro Michael,
Sosis Arthur C.,
JunkinsHopkins Jacqueline M.,
Werth Victoria P.
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02013.x
Subject(s) - medicine , dermatology , lupus erythematosus , subacute cutaneous lupus erythematosus , systemic lupus erythematosus , immunology , disease , connective tissue disease , pathology , autoimmune disease , antibody
Exogenous agents implicated in or suspected of precipitating subacute cutaneous lupus erythematosus (SCLE) and lupus erythematosus (LE) are reviewed. An illustrative case of environmentally induced SCLE is presented. A previously healthy 30‐year male homozygous for the tumor necrosis factor‐α (TNF‐α) 308. A promoter allele developed SCLE after spending several hours removing fertilizer‐ and pesticide‐containing hay from an agricultural barn in the springtime. The cutaneous eruption soon resolved, only to reappear 3 weeks later on the day the patient re‐entered the barn. An environmental agent present in the barn, coupled with springtime ultraviolet light, likely triggered the disease in this immunogenetically susceptible individual.