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Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime®) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime®) alone for the treatment of cutaneous leishmaniasis
Author(s) -
Asilian A.,
Sadeghinia A.,
Faghihi G.,
Momeni A.
Publication year - 2004
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2004.02002.x
Subject(s) - meglumine antimoniate , cryotherapy , medicine , cutaneous leishmaniasis , meglumine , dermatology , leishmaniasis , surgery , pathology , magnetic resonance imaging , radiology
Background Cutaneous leishmaniasis (CL) is a parasitic disease caused by Leishmania species. There is a need for more effective and less time‐consuming therapeutic methods for this condition. Aim To evaluate the efficacy of combined cryotherapy and intralesional meglumine antimoniate (MA) (Glucantime®, Specia, Paris, France) for the treatment of CL. Methods Patients were divided into three groups: Group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional MA; Group 2, 200 patients with 230 lesions were treated with cryotherapy; Group 3, 100 patients with 160 lesions were treated with intralesional MA. These groups were followed for 6 months after the end of treatment. Results The results showed complete cure in 90.9% of cases in Group 1, 57.15% of cases in Group 2, and 55.63% of cases in Group 3. The difference between Group 1 and the other groups was statistically significant ( P < 0.05). Conclusions Combined cryotherapy and intralesional MA is more effective than either cryotherapy or intralesional MA alone for the treatment of CL.