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CUTANEOUS LEISHMANIASIS: SCHEDULES FOR INTRALESIONAL TREATMENT WITH SODIUM STIBOGLUCONATE
Author(s) -
TALLAB TALAL M.,
BAHAMDAM KHALID A.,
MIRDAD SOLEMAN,
JOHARGI HANAN,
MOURAD MOHAMED MAZE.,
IBRAHIM KARAM,
SHERBINI ABDUL HAMEED,
KARKASHAN EMAN,
KHARE ASHOK KUMAR,
JAMAL AWATIF
Publication year - 1996
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1996.tb03669.x
Subject(s) - sodium stibogluconate , medicine , cutaneous leishmaniasis , leishmaniasis , protozoal disease , dermatology , surgery , immunology , malaria
Background. Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated. Methods. Ninety‐six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule. Results. The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate‐day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%. Conclusions. Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.