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ULTRASTRUCTURE AND HUMAN PAPILLOMAVIRUS DNA IN PAPILLOMATOSIS OF EXTERNAL AUDITORY CANAL
Author(s) -
XIA MINGYU,
ZHU WENYUAN,
LU JUNGYU,
LU QIN,
CHEN LEI
Publication year - 1996
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1996.tb03634.x
Subject(s) - medicine , papillomatosis , auditory canal , ultrastructure , human papillomavirus , pathology , anatomy
Background. A viral etiology has been suspected in papillomatosis of the external auditory canal ( peac ), but virus particles have not been detected so far, although they are easily demonstrable in skin warts. The purpose of the study was to solve this discrepancy by the use of polymerase chain reaction ( pcr ). Materials and Methods. Specimens from the external auditory canal of 14 patients with PEAC, but no human papilloma virus infection of the genital areas, were examined histologically by light and electron microscopy, as well as by PCR to detect viral dna . Results. Histologically, papillomatosis was present in all specimens. Vacuolated cells were found in the upper part of the stratum malpighii in five cases. On electron microscopy, the numbers of perichromatin and interchromatin granules were increased, but no viral granules were observed. In all specimens, dna of hpv 6 was detected using PCR, but there was no evidence of DNA of other hpv . Conclusions. Papilloma of the external auditory canal is produced by infection with hpv 6.