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POST‐KALA‐AZAR DERMAL LEISHMANIASIS: A CLINICAL AND THERAPEUTIC STUDY
Author(s) -
RAMESH VENKATESA,
MISRA RADHEY SHYAM,
SAXENA UMA,
MUKHERJEE ASHOK
Publication year - 1993
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1993.tb04266.x
Subject(s) - medicine , leishmaniasis , dermatology , visceral leishmaniasis , protozoal disease , immunology , malaria
Background. Post‐kala‐azar dermal leishmaniasis is a condition peculiarly confined to the Indian subcontinent. Methods. The clinical features and investigations in 18 patients of post‐kala‐azar dermal leishmaniasis were studied. Results. There was a polymorphic picture from hypopigmented macules to nodules and plaques. Mucous membranes were affected in five, the lips and glans penis being the most frequent sites, Histopathologically, a rich dermal infiltrate was seen in indurated lesions and in macules; it was confined to perivascular foci in the upper dermis. Leishman‐Donovan bodies were seen in 16. Conclusions. The lesions cleared in 4 to 5 months after treatment with sodium antimony gluconate intramuscularly 20 mg/kg/day up to a maximum of 1 g/day. The drug was well tolerated.