Premium
CONCURRENT HPV‐16 INFECTION OF THE NIPPLE AND PERI ANAL AREA IN AN HIV‐1+ PATIENT
Author(s) -
SMITH LTC KATHLEEN J.,
SKELTON CDR HENRY G.,
HAWKS LTC CLIFFORD,
YEAGER CDR JOSEF,
WAGNER KENNETH F.
Publication year - 1993
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1993.tb04023.x
Subject(s) - medicine , lesion , human immunodeficiency virus (hiv) , pathology , virus , viral disease , disease , virology
Background. In patients with HIV‐1 disease there has been an increasing association with human papilloma virus (HPV) infections in multiple locations as well as an increase in associated tumors. In addition, there has been increased recovery of HPV in individuals with decreasing T4 cell counts. Case Report. Recently we have seen an HIV‐I+ patient with a cutaneous lesion on the nipple, as well as multiple perianal lesions in which HPV‐16 was demonstrated by in‐situ hybridization. Although these lesions contained the same subtype of HPV virus, they had very different clinical and histopathologic morphologies, and this represents the first reported association of HPV‐16 in a nipple lesion. Discussion. Our patient illustrates that in HIV‐I disease, HPV infections may present in more diffuse and atypical locations. In addition, the diffuse staining with the in‐situ probe for HIV‐16 within the lesions, tends to support the findings of others, that viral recovery increases with the immune suppression induced by HIV‐I.