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PSORIASIS‐LIKE LESIONS IN GUINEA PIGS RECEIVING PROPRANOLOL
Author(s) -
TÜZÜN BINNUR,
TÜZÜN YALÇIN,
GÜREL NURAY,
TÜZÜNER NÜKHET,
ALTUG TUNCAY,
BÜYÜKDEVRIM SEVIM
Publication year - 1993
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1993.tb01456.x
Subject(s) - medicine , propranolol , psoriasis , dermatology , guinea pig
Background . β‐Blockers cause a psoriasiform eruption. We investigated the skin effects of systemic propranolol in a formal protocol. Methods . Propranolol, 0.1 mg/day, was used systemically by gavage in eight albino guinea pigs. Normal saline was given to another group of seven guinea pigs. Results . Propranolol produced psoriasiform lesions in five of seven guinea pigs on the 30th day. Biopsies showed acanthosis, parakeratosis, microabscesses, and cellular infiltration of upper dermis. Topical application of propranolol did not produce clinical psoriasiform changes, while acanthosis and papillomatosis was observed in six of the six guinea pigs. Conclusions . Systemically given propranolol can lead to psoriasis‐like lesions, which might be due to a serum factor.