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LEPROMATOUS LEPROSY TREATED WITH RECOMBINANT INTERFERON GAMMA: CUTANEOUS HISTOLOGIC CHANGES
Author(s) -
BOTTASSO OSCAR,
BESUSCHIO SANTIAGO,
MERLIN VICTOR,
MORINI JULIO C.,
BERNABO JORGE,
FALCOFF REBECA,
FALCOFF ERNESTO
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb04253.x
Subject(s) - medicine , leprosy , lepromatous leprosy , intradermal injection , adverse effect , mycobacterium leprae , immunology , recombinant dna , peripheral blood mononuclear cell , local reaction , interferon gamma , dermatology , cytokine , in vitro , biochemistry , gene , chemistry
We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 jag each, of recombinant interferon gamma (nFN‐γ). Except for a strong induration at the injection site, nFN‐γ produced no adverse systemic reactions and was able to promote a remarkable influx of T‐lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced lysozyme reactivity. Furthermore, despite no clear‐cut reduction of mycobacterial dermal burden, bacilli showed a clear increase in the granular appearance. Present findings provide a basis for further elucidation of nFN‐γ as an additional tool for leprosy treatment.