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HEMOSTASIS AND PLATELET AGGREGATION IN I'URPURIC PIGMENTED ANGIODERMATITIS ERUPTIONS
Author(s) -
VIGNALF RAUL,
RIZZO MARGARITA GARCIA
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb04244.x
Subject(s) - platelet , high molecular weight kininogen , coagulation , fibrinolysis , medicine , hemostasis , von willebrand factor , thrombocytosis , clot retraction , mean platelet volume , clotting factor , platelet factor 4 , platelet activation , factor xii , immunology , pathology , endocrinology , platelet aggregation , kininogen , bradykinin , receptor
Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid‐like purpura angiodermatitis were studied with current hemostasis parameters: (I) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and high molecular weight kininogen (HMWK) in their coagulation fraction. The results showed: (I) reactional thrombocytosis with morphologic changes; (2) increased levels of platelet circulating aggregates; (3) increased response of platelet aggregation to different agonists, especially at very low doses, and also when we used washed platelets resuspended in normal plasma; (4) delayed activation of the contact system; (5) decrease of the activity of the fibrinolysis activators; and (6) diminished function activity of the HMWK coagulation fraction. As a physiopathogenic hypothesis In these patients, there is a cutaneous pathology that could be entailed to these hematologic alterations of the platelet‐HMWK‐endothelial cellskinins‐coagulation‐fibrinolysis system.