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TOXIC EPIDERMAL NECROLYSIS
Author(s) -
PARSONS JEROME M.
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb04238.x
Subject(s) - toxic epidermal necrolysis , medicine , dermatology , mucocutaneous zone , erythema , erythroderma , pathology , disease
Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell 1 of Glasgow, Scotland, and Lang and Walker 2 of Cape Town, South Africa, independently described this syndrome in 1956. Lyell was responsible for coining the term “toxic epidermal necrolysis.” Toxic referred to a presumed circulating toxin responsible for producing both the prodrome and the eruption. Epidermal referred to the presence of significant epidermal damage with comparatively slight dermal reaction. Necrolysis was a neologism combining the pathologic finding of necrosis with the clinical finding of epidermolysis. 1,3,4