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TOPICAL CORTICOSTEROIDS: QUALITY CONTROL CONSIDERATIONS
Author(s) -
SHAH VINOD P.
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb04011.x
Subject(s) - medicine , chromatography , drug , diffusion , quality (philosophy) , pharmacology , biomedical engineering , chemistry , philosophy , physics , epistemology , thermodynamics
Abstract A simple procedure is developed, which can be used as a quality control test. The method utilizes commercially available diffusion cell assembly, synthetic membrane, and an appropriate receptor phase. The amount of drug released over time is determined using an HPLC method. From this, the drug release rate, flux, μg/cm 2 /min 0.5 is calculated. This drug release rate can serve as a good quality control test to assure batch‐to‐batch uniformity.