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REACTION IN LEPROSY: ACUTE PHASE REACTANT RESPONSE DURING AND AFTER REMISSION
Author(s) -
SEHGAL VIRENDRA N.,
BHATTACHARYA SAMBIT N.,
SHAH YASHODHARA,
SHARMA VINAY K.,
GUPTA CHANDER K.
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb03981.x
Subject(s) - medicine , leprosy , erythema nodosum , c reactive protein , erythema , acute phase protein , immunology , dermatology , disease , inflammation
Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha‐1–antitrypsin (AIA) and C‐reactive protein (CRP). The results were compared with those from normal healthy adults and patients of leprosy without history and/or clinical evidence of reaction. The AIA levels correlated better with changes in status of type 1 reaction; whereas CRP levels correlated well with alterations in type 2 reactions and were definitely superior to AIA in this situation for monitoring the course of these episodes.