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NONSEGMENTAL VITILIGO: DECREASE OF THE CD45RA+ T‐CELL SUBSET AND EVIDENCE EOR PERIPHERAL T‐CELL ACTIVATION
Author(s) -
ABDELNASER M. BADAWY,
LUDWIG WOLFDIETER,
GOLLNICK HARALD,
ORFANOS CONSTANTIN E.
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb03946.x
Subject(s) - vitiligo , cd8 , medicine , cd3 , t cell , t cell receptor , immunology , il 2 receptor , pathogenesis , peripheral t cell lymphoma , human leukocyte antigen , peripheral , cd16 , t lymphocyte , antigen , immune system
Abstract Peripheral T‐lymphocytes from 16 randomly selected patients with nonsegmental vitiligo were labeled with monoclonal antibodies recognizing T‐cell receptor (TCR) α/β, TCR γ/δ, CD3, CD4, CD8, CD45RA, CD45RO, CD11b, CD11C, CD16, CD56, CD25, CD54, and HLA‐DR antigens. In comparison with matched controls, a significant decrease of the CD45RA+ subset (P < 0.03) together with significant increase of the circulating HLA‐DR‐I‐ cells (P< 0.02) was found. No other alterations were detected. These findings may point to some autoimmune phenomena involved in the pathogenesis of the disease. The increased HLA‐DR expression indicates the presence of activated peripheral T‐cells. Thus, our data provide new and further evidence for T‐cell dysregulation in nonsegmental vitiligo.