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FACIAL PYOGENIC GRANULOMA‐LIKE LESIONS UNDER ISOTRETINOIN THERAPY
Author(s) -
HAGLER JOSEPH,
HODAK EMMILIA,
DAVID MICHAEL,
SANDBANK MIRIAM
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb03936.x
Subject(s) - medicine , isotretinoin , pyogenic granuloma , etiology , granulation tissue , tretinoin , acne , dermatology , retinoic acid , pathology , surgery , lesion , biochemistry , chemistry , wound healing , gene
A male patient with severe cystic acne was treated with 13‐cis‐retinoic acid in a dosage of 1 mg/kg/day. Early flare‐up of his acne and multiple pyogenic‐like lesions on his face appeared during the second week of isotretinoin treatment. Histologic study of the lesions revealed granulation tissue. Possible etiologies for this phenomenon are discussed.