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PERIPHERAL T LYMPHOCYTES AND THEIR SUBSETS IN CUTANEOUS TUBERCULOSIS
Author(s) -
SEHGAL VIRENDRA N.,
WAGH SUNEITA A.,
BHATTACHARYA SAMBIT N.,
SHARMA VINAY K.
Publication year - 1992
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4362.1992.tb03249.x
Subject(s) - lupus vulgaris , medicine , cd8 , tuberculosis , immunology , cd3 , cutis , cytotoxic t cell , monoclonal antibody , staining , pathology , immune system , antibody , biology , biochemistry , in vitro
Fifty‐four patients with cutaneous tuberculosis, consisting of 23 with lupus vulgaris,22 with scrofuloderma, and nine with verrucosa cutis, were investigated for cell‐mediated immunity, through estimation of peripheral total T lymphocytes (CD3+), CD4+ (helper/inducer), and CD8+ (cytotoxic/suppressor) lymphocytes, by immunohistochemical staining of peripheral blood smears, using specific monoclonal antibodies and the alkaline phosphatase‐antialkaline phosphatase (APAAP) method. Absolute values of total T lymphocytes (CD3+), and CD4+ and CD8+ subsets, were found to be significantly raised in scrofuloderma, but the percentage values and the CD4+/CD8+ ratio remained unaltered. In tuberculosis verrucosa cutis, only the percentage of the CD8+ subset of T lymphocytes was found to be significantly lowered, and this altered the CD4+/CD8+ ratio. No significant change was observed in the peripheral blood T cells and their subpopulations in patients suffering from lupus vulgaris.